Pharmacology department of ASMU SIC under supervision of biological sciences, professor R.A.Akhundov, is conducting investigations by search and implantation of anti-hypoxants and cerebroprotectors on base of proendogenous remedies and vitamin like formulas with original structure. 

     Effects of nikotinamide, inosine, glutamates, pyrrolopyridies are being studied by psychopharmacological methods on caused hypoxic status during experimental studies of mnestical and consolidating factors, including bad-studying and old animal. 

     New antihypoxants and psykho-crerectors: meksidol, nooglutil, nikomorpholine and other new remedies are optimizing free radical processes, and inhibiting lipid peroxidation (LPO), improving brain blood circulation disturbed by hypoxia and serotonine, reclining orientation processes in V- and T-shape labyrinths, activating operant transfer or on hypoxia and alcohol background. In mechanism of formulas effects prevailed agonistic on GAOA-glutamate benzodiarepine-receptor complex. 

     Efficiency of new remedies is expressed in cerebrodinamics anxio- litic, anticonflict and antiagregation actions. Responding to effect direction new antihypoxants and psykhoregulatories are  applicable as correctors of cerebro-vascular disbalance and brain hypoxia burring rehabilitation of post-insult patients, accompanying by speech and memory disturbances as remedies for treatment of children with mental development defects? In some forms of memory deviations of background of alcoholism and drug-addict, ALTS-geimer's disease, atherosclerosis demention. 

   Responding to the data obtained, proposed new-kinds psycho-regulators on base of vitamins and gluthamine acid or founding application in extreme situations, requiring extraordinary decisions, for example global cataclysms, ecological accidents, mass psychoses in cases, requiring mobilization and coordination of all adaptation mechanism, depending homeostasis of person in stress situation. 

For more information about this article please contact with following address:

 Akhundov Ramiz, 

doctor of medical science, Azerbaijan State Medical University named after N.Narimanov, Fharmacology Department  

Tel.: 99412 95 54 16 ; 99412 95 43 86 

POSSIBLITES OF ADMINISTRATION OF INTRAVENOUS LASER THERAPY IN THE COMPLEX TREATMENT OF PATIENTS WITH CARDIOMYOPATHY WITH CARDIAC INSUFFICIENCY 

Khalilov A.N., Ibragimov F.Sh., Azizov V.A., Agayeva T.V.

 SRI of Cardiology, Baku, Azerbaijan 

    Intravenous laser therapy (ILT) was administered to 28 patients (pts) with chronic heart insufficiency of II A ( 7pts) and II B (21 pts) stages by the classification of N.D. Strajesco and V.Kh. Vasilenco.

   Dilatatedl cardiomyopathy (HCMP) was found in 4 patients, coronary heart disease (IHD) in 5 patients, IHD with concomitant arterial hyper- tension (AH) in 7 patiens, stable ventricular arrhythmia (VA) in 12 patients. 

   ILT with simultaneous use of aevit and esseciale in capcules was administered at the background of treatment by cardiac glycosides, ATP-inhibitors, diuretics (veroshpiron, furosemid), aspirin, which during of 7-10 days didn't induce essential improvement of state of patients (tachycardia, VA, congestive features in greater and lesser circulation's were preserved). 

    Courses of ILT were carried out daily 30 min during 507 days with the power of radiation 0,7-1 mVt. It should be noticed that beginning from II session in 10 pts with DCMP and in 10 patiens with IHD with CD of II B stage increase of diuretics with further disappearance of congestive features by the end of course treatment by ILT were observed. At the background of medicament treatment (antiarithmic drugs and b-blockers were not used. In 4 patients with CE of II A stage ( 2 with HCMP, 2 with IHD) a long-term improvement of patients state before including of ILT was achieved. But stable VA at these patients was prevented. At the end of ILT course treatment in become possible remove stable VA in all 4 patients with CD II A stage and in 6 patients with CD II B stage. 

     Thus, we consider expedient the including of ILT to the complex treatment of the patients with insufficiency of ishaemia genesis and with DCMP an HCMP.  

For more information about this article please contact with following address: 

Khalilov Ariz Nurulla ogli ,

medical science candidate, SRI of Cardiology named after academitian D.M Abdullaev, Baku, Azerbaijan 

Home adress: F. Khoyski Str. 101, Baku, Azerbaijan 

Tel : 99412 76 24 71

 PREDICTORS OF THE BAD FORECAST AT LONG TREATMENT OF A HERT FAILURE BY CAPTORILUM OF THE CHD PATIENTS WITH PACEMAKER'S 

Bakhshiev M.M. 

Medical University and Scientific Institute of surgery of Baku, Azerbaijan 

      With the purpose of definition of predictors of the bad forecast at long treatment of a heart failure by Captoprilum (capoten, firm Bristol-Myers Squibb, USA) of CHD patients with pacemaker's with a heart failure 1-3 FC( NIHA) on the average age of 58,4~3.2 years which are found in various a long time till 5 years received capoten + diutretics (if necessary, with addition of digoxine). 

     The methods of the control were veloergometry, spiroergometry, echocardiography, right-hand catheterization of heart. The analysis of survival rate was made by a method Kaplan-Meier. Fixed, that use of veloergonometry and sproergometry allows to reveal early infringements of a hemodynamycs at the CHD patient with ECS. It is particular informative on this aspect of dynamics of changes of hemodynamic parameters at performance of an isometric load on the data of a right-hand cardiac catheterization. 

      There was a prognostically combination of an appreciable gain of total pulmonary vascular resistance with a very low gain or even by downstroke of pulmonary capillary wedge pressure at height of a load; sharp rising of a gain of an index of shock work of a left ventricle at a load; a rather high gain of diastolic pressure in a trunk of a pulmonary artery in early terms after an implantation of ECS. 

       It has been shown, that revealing of the brokenhemodynamics at the patients with CHD by ECS at a doses exercise stress, especially, in rest can be predictorsof the bad forecast for a survival at long observation. 

For more information about this article please contact with following address:

 Bakhshiev Murad, 

Doctor of medical science, professor, Chair of internal diseases of Azerbaijan State Medical University named after N.Narimanov 

Adress: 38/35 Tabibli Str, 370122 Baku, Azerbaijan 

Тel.: + 99412 94 18 23 Fax: + 99412 97 37 84 E-mail: tamc@azeuro.net  muradali@mail.ru 

EFFECT OF IMMUNE STATE CHANGES ON CLINICAL COURSEOF DIFFUSED PURULENT PERITONITIS AND THEIR COOOERTION IN THE EARLY POSTOPERATIVE PERIOD

A. A. Akhundbeyli, I. Sh Maherrembeyli, I.S. Ismailov

N.N.Narimanov Azerbaijan Medical University, 1-st department of internal diseases and Resuscitology, Baku

    134 patients with diffused purulent peritonitis (DPP) underwent complex investigation of the immune state . 

     On the basis of retrospective analysis of obtained data it was revealed that in patients with DPP a secondary immunodeficiency is naturaly noted and the degree of immune indeces changes considerably predetermines the outcome of disease: average 15-30% decrease of the parameters points as positive outcome and 30-50% decrease is frequent an indication of unfavourable result. 

     It was found out that complex use of HBO seccions, intravascular lazer blood and thumaline irradiatin has an expressive immunocorrigating effect and promote lowering of a number of complications in postoperative period and decrease of lethality.